Quick Answer: What Are The Symptoms Of Low IgG?

How common is IgG deficiency?

IgG2 or IgG3 deficiencies are the most common IgG subclass deficiencies.

Since IgG1 comprises 60% of the total IgG level, deficiency of IgG1 usually drops the total IgG level below the normal range, resulting in hypogammaglobulinemia.

IgG subclass deficiencies may be associated with other immunoglobulin abnormalities..

Is IgG deficiency an autoimmune disease?

Autoimmune diseases were more frequent in CVID patients (37.1 %) than in those with selective IgA deficiency (25.5 %) or selective IgG subclass deficiency (12.5 %). Thirty-seven percent of autoimmune episodes occurred prior to the diagnosis of primary antibody deficiency.

What does low IgG and IgM mean?

For example, IgM antibodies for mononucleosis with or without IgG antibodies means a new mono infection. IgG antibodies without IgM means a past mono infection. People with very low immunoglobulin levels, especially IgA, IgG, and IgM, have a higher chance of developing an infection.

Is low IgG serious?

People with IgG deficiency are more likely to get infections. Although researchers don’t know what causes primary IgG deficiency, genetics may play a role. When the symptoms come on later in life, the health problem is harder to manage, and you may have more infections.

Can low IgG levels cause fatigue?

Isolated IgG1 deficiency has been reported in chronic fatigue syndrome. As IgG1 is the most abundant IgG subclass, its deficiency often results in hypogammaglobulinemia. Conversely, IgG2 and IgG4 deficiencies manifest in the form of otitis media and sinusitis.

What does IgG blood test show?

An immunoglobulins blood test may be used to help diagnose a variety of conditions, including: Bacterial or viral infections. Immunodeficiency, a condition that reduces the body’s ability to fight infections and other diseases. An autoimmune disorder, such as rheumatoid arthritis or lupus.

How do you treat low IgG levels?

Currently, the accepted therapy for IgG deficiency is the intravenous administration of 300-600 mg/kg of IgG once every 3-4 weeks, or 100-200 mg/kg/wk subcutaneously. Higher doses have been shown to be more effective in reducing infections in patients with histories of chronic or recurrent sinopulmonary infections.

What does it mean when your IgG is low?

An IgG deficiency is a health problem in which your body doesn’t make enough Immunoglobulin G (IgG). People with IgG deficiency are more likely to get infections. IgG deficiencies can occur at any age. When your body feels it is under attack, it makes special proteins called immunoglobulins or antibodies.

What diseases cause low IgG?

Infections that most often affect people with IgG deficiency are:Sinus infections and other respiratory infections.Digestive tract infections.Ear infections.Pneumonia.Bronchitis that keeps coming back. … Infections that cause a sore throat.Severe and life-threatening infections (rare)

What can cause low IgM?

Other causes of decreased levels of serum IgM (i.e., secondary IgM deficiency) are episodes of infection, thymic hypoplasia, celiac disease, autoimmune disease, and certain adult malignancies; and other PIDs (Wiskott-Aldrich syndrome, DOCK8 deficiency, ataxia-telangiectasia, CVID, and XLA, in combination with IgG and …

How can I increase my IgG naturally?

Eat Right Garlic. Omega-3 fatty acids, found in nuts, salmon, tuna, mackerel, and flaxseed oil. Zinc-rich foods, like oysters, crab, lean meats and poultry, and chickpeas. Selenium-rich foods, such as broccoli, sardines, tuna, brazil nuts, and barley.